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Recent publications

Articles

1.   Pomozi V, Le Saux O, Brampton CN, Apana AL, Iliás A, Martin L, Szeri F, Monostory K, Paku S, Sarkadi B, Szakács G and Varadi A (2013) [23625951]
  ABCC6 is a Basolateral Plasma Membrane Protein.
  Circ Res notSet,
2.   Tátrai P, Sági B, Szigeti A, Szepesi A, Szabó I, Bősze S, Kristóf Z, Markó K, Szakács G, Urbán I, Mező G, Uher F and Német K (2012) [23135412]
  A novel cyclic RGD-containing peptide polymer improves serum-free adhesion of adipose tissue-derived mesenchymal stem cells to bone implant surfaces.
  J Mater Sci-mater M notSet,
3.   Kasza I, Várady G, Andrikovics H, Koszarska M, Tordai A, Scheffer GL, Németh A, Szakács G and Sarkadi B (2012) [23166586]
  Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations.
  PLoS ONE 7, e48423
4.   Hegedüs C, Truta-Feles K, Antalffy G, Várady G, Német K, Ozvegy-Laczka C, Kéri G, Orfi L, Szakács G, Settleman J, Váradi A and Sarkadi B (2012) [22548830]
  Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance.
  Biochem Pharmacol 84, 260-7
5.   Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, Vallentin A, Vial H, Vidal M and Szakacs G (2012) [22655043]
  Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes.
  PLoS ONE 7, e37378
6.   Szentpetery Z, Szakacs G, Bojjireddy N, Tai AW and Balla T (2011) [21601653]
  Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIα.
  Biochim Biophys Acta 1811, 476-83
7.   Tamaki A, Ierano C, Szakacs G, Robey RW and Bates SE (2011) [21967059]
  The controversial role of ABC transporters in clinical oncology.
  Essays Biochem. 50, 209-32
8.   Brózik A, Hegedüs C, Erdei Z, Hegedus T, Özvegy-Laczka C, Szakács G and Sarkadi B (2011) [21410427]
  Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?
  Expert Opin Drug Met 7, 623-42
9.   Sarkadi B, Orbán TI, Szakács G, Várady G, Schamberger A, Erdei Z, Szebényi K, Homolya L and Apáti A (2010) [19924769]
  Evaluation of ABCG2 expression in human embryonic stem cells: crossing the same river twice?
  Stem Cells 28, 174-6
10.   Sarkadi B and Szakács G (2010) [21031004]
  Understanding transport through pharmacological barriers - are we there yet?
  Nat Rev Drug Discov 9, 897-8
11.   Katona M, Kiss K, Angyal V, Kucsma N, Sarkadi B, Takáts Z and Szakács G (2009) [19780062]
  A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity.
  Rapid Commun Mass Sp 23, 3372-3376
12.   Türk D, Hall MD, Chu BF, Ludwig JA, Fales HM, Gottesman MM and Szakács G (2009) [19843850]
  Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells.
  Cancer Res 69, 8293-301
13.   Hegedus C, Szakács G, Homolya L, Orbán TI, Telbisz A, Jani M and Sarkadi B (2009) [19135105]
  Ins and outs of the ABCG2 multidrug transporter: an update on in vitro functional assays.
  Adv Drug Deliver Rev 61, 47-56
14.   Hegedus C, Ozvegy-Laczka C, Szakács G and Sarkadi B (2009) [19442047]
  Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and/or inhibitors?
  Curr Cancer Drug Tar 9, 252-72
15.   Hegedűs C, Ozvegy-Laczka C, Apáti A, Magócsi M, Német K, Orfi L, Kéri G, Katona M, Takáts Z, Váradi A, Szakács G and Sarkadi B (2009) [19785662]
  Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties.
  Brit J Pharmacol 158, 1153-64
16.   Türk D and Szakács G (2009) [19333870]
  Relevance of multidrug resistance in the age of targeted therapy.
  Curr Opin Drug Disc 12, 246-52
17.   Hall MD, Salam NK, Hellawell JL, Fales HM, Kensler CB, Ludwig JA, Szakács G, Hibbs DE and Gottesman MM (2009) [19397322]
  Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.
  J Med Chem 52, 3191-204
18.   Okabe M, Szakács G, Reimers MA, Suzuki T, Hall MD, Abe T, Weinstein JN and Gottesman MM (2008) [18790787]
  Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters.
  Mol Cancer Ther 7, 3081-91
19.   Szakács G, Váradi A, Ozvegy-Laczka C and Sarkadi B (2008) [18468555]
  The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
  Drug Discov Today 13, 379-393
20.   Paterson JK, Shukla S, Black CM, Tachiwada T, Garfield S, Wincovitch S, Ernst DN, Agadir A, Li X, Ambudkar SV, Szakacs G, Akiyama S and Gottesman MM (2007) [17661442]
  Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.
  Biochemistry-us 46, 9443-52
21.   Fuller MD, Thompson CH, Zhang ZR, Freeman CS, Schay E, Szakács G, Bakos E, Sarkadi B, McMaster D, French RJ, Pohl J, Kubanek J and McCarty NA (2007) [17951250]
  State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin.
  J Biol Chem 282, 37545-55
22.   Gottesman MM, Ludwig J, Xia D and Szakács G (2006) [17234123]
  Defeating drug resistance in cancer.
  Discovery medicine 6, 18-23
23.   Fang L, Zhang G, Li C, Zheng X, Zhu L, Xiao JJ, Szakacs G, Nadas J, Chan KK, Wang PG and Sun D (2006) [16451059]
  Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance.
  J Med Chem 49, 932-41
24.   Sarkadi B, Homolya L, Szakács G and Váradi A (2006) [17015488]
  Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system.
  Physiol Rev 86, 1179-236
25.   Ludwig JA, Szakács G, Martin SE, Chu BF, Cardarelli C, Sauna ZE, Caplen NJ, Fales HM, Ambudkar SV, Weinstein JN and Gottesman MM (2006) [16651436]
  Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.
  Cancer Res 66, 4808-15
26.   Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C and Gottesman MM (2006) [16518375]
  Targeting multidrug resistance in cancer.
  Nat Rev Drug Discov 5, 219-34
27.   Ambudkar SV, Sauna ZE, Gottesman MM and Szakacs G (2005) [15978680]
  A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1).
  Trends Pharmacol Sci 26, 385-7
28.   Liang XJ, Taylor B, Cardarelli C, Yin JJ, Annereau JP, Garfield S, Wincovitch S, Szakács G, Gottesman MM and Aszalos A (2005) [16309205]
  Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance.
  Anticancer Res 25, 4113-22
29.   Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ and Gottesman MM (2005) [15760339]
  Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.
  Pigment Cell Res 18, 102-12
30.   Annereau JP, Szakács G, Tucker CJ, Arciello A, Cardarelli C, Collins J, Grissom S, Zeeberg BR, Reinhold W, Weinstein JN, Pommier Y, Paules RS and Gottesman MM (2004) [15342794]
  Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance.
  Mol Pharmacol 66, 1397-405
31.   Szakacs G and Gottesman MM (2004) [15616161]
  Comparing solid tumors with cell lines: Implications for identifying drug resistance genes in cancer
  Mol Interv 4, 323-5
32.   Wu JE, Basso F, Shamburek RD, Amar MJ, Vaisman B, Szakacs G, Joyce C, Tansey T, Freeman L, Paigen BJ, Thomas F, Brewer HB and Santamarina-Fojo S (2004) [15044450]
  Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice.
  J Biol Chem 279, 22913-25
33.   Szakács G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN and Gottesman MM (2004) [15324696]
  Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells.
  Cancer Cell 6, 129-37
34.   Szakács G, Chen GK and Gottesman MM (2004) [14976423]
  The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance.
  Cancer Biol Ther 3, 382-4
35.   Lee JK, Bussey KJ, Gwadry FG, Reinhold W, Riddick G, Pelletier SL, Nishizuka S, Szakacs G, Annereau JP, Shankavaram U, Lababidi S, Smith LH, Gottesman MM and Weinstein JN (2003) [14659019]
  Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells.
  Genome Biol 4, R82
36.   Váradi A, Szakács G, Bakos E and Sarkadi B (2002) [11990782]
  P glycoprotein and the mechanism of multidrug resistance.
  Novartis Found Symp 243, 54-65; discussion 65
37.   Karászi E, Jakab K, Homolya L, Szakács G, Holló Z, Telek B, Kiss A, Rejtô L, Nahajevszky S, Sarkadi B and Kappelmayer J (2001) [11167823]
  Calcein assay for multidrug resistance reliably predicts therapy response and survival rate in acute myeloid leukaemia.
  Brit J Haematol 112, 308-14
38.   Szakács G, Langmann T, Ozvegy C, Orsó E, Schmitz G, Váradi A and Sarkadi B (2001) [11700048]
  Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter.
  Biochem Bioph Res Co 288, 1258-64
39.   Ozvegy C, Litman T, Szakács G, Nagy Z, Bates S, Váradi A and Sarkadi B (2001) [11437380]
  Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
  Biochem Bioph Res Co 285, 111-7
40.   Szakács G, Özvegy C, Bakos É, Sarkadi B and Váradi A (2001) [11336637]
  Role of glycine-534 and glycine-1179 of human multidrug resistance protein (MDR1) in drug-mediated control of ATP hydrolysis.
  Biochem J 356, 71-5
41.   Bakos É, Evers R, Calenda G, Tusnády GE, Szakács G, Váradi A and Sarkadi B (2000) [11082039]
  Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1).
  J Cell Sci 113 (Pt 2), 4451-61
42.   Smith AJ, van Helvoort A, van Meer G, Szabó K, Welker E, Szakács G, Varadi A, Sarkadi B and Borst P (2000) [10918072]
  MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
  J Biol Chem 275, 23530-9
43.   Szakács G, Özvegy C, Bakos É, Sarkadi B and Váradi A (2000) [11027628]
  Transition-state formation in ATPase-negative mutants of human MDR1 protein.
  Biochem Bioph Res Co 276, 1314-9
44.   Szabó K, Szakács G, Hegedűs T and Sarkadi B (1999) [10212185]
  Nucleotide occlusion in the human cystic fibrosis transmembrane conductance regulator. Different patterns in the two nucleotide binding domains.
  J Biol Chem 274, 12209-12
45.   Szakács G, Jakab K, Antal F and Sarkadi B (1998) [9887354]
  Diagnostics of multidrug resistance in cancer.
  Pathol Oncol Res 4, 251-7
46.   Bakos É, Evers R, Szakács G, Tusnády GE, Welker E, Szabó K, de Haas M, van Deemter L, Borst P, Váradi A and Sarkadi B (1998) [9822694]
  Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain.
  J Biol Chem 273, 32167-75
47.   Holló Z, Homolya L, Hegedûs T, Müller M, Szakács G, Jakab K, Antal F and Sarkadi B (1998) [9713496]
  Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1.
  Anticancer Res 18, 2981-7
48.   Ferenczi A, Homolya V, Szakács G, Németh K, Kiss E, Váradi A and Fekete G (1997) [9072754]
  [Clinical application of analysis of microsatellite markers in the prenatal diagnosis of cystic fibrosis]
  Orv Hetil 138, 209-13

Books or book chapters

1.   Szakács G, Kin Wah To K, Polgar O, Robey R and Bates S (2009)
  Multidrug Resistance Mediated by MDR ABC Transporters
  Drug Resistance in Cancer Cells ISBN: 978-0-387-89444-7,
2.   Szakács G and Sarkadi B (2003)
  Modulation of drug effects by ABC transporters
  Molecular Pathomechanisms and New Trends in Drug Research ISBN: 0-415-27725-6,
3.   Varadi A, Szakács G, Bakos E and Sarkadi B (2002)
  P glycoprotein and the Mechanism of Multidrug Resistance
  Mechanisms of Drug Resistance in Epilepsy ISBN: 047084146X,