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Recent publications

Articles

1.   Megyeri M, Harmat V, Major B, Végh Á, Balczer J, Héja D, Szilágyi K, Datz D, Pál G, Závodszky P, Gál P and Dobó J (2013) [23386610]
  Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway.
  J Biol Chem 288, 8922-34
2.   Láng A, Major B, Szilágyi K, Gáspári Z, Gál P, Závodszky P and Perczel A (2010) [20970424]
  Interaction between separated consecutive complement control modules of human C1r: Implications for dimerization of the full-length protease.
  FEBS Lett 584, 4565-4569
3.   Láng A, Szilágyi K, Major B, Gál P, Závodszky P and Perczel A (2010) [20796027]
  Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology.
  FEBS J 277, 3986-98
4.   Kardos J, Harmat V, Palló A, Barabás O, Szilágyi K, Gráf L, Náray-Szabó G, Goto Y, Závodszky P and Gál P (2008) [17996945]
  Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r.
  Mol Immunol 45, 1752-60
5.   Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G and Závodszky P (2004) [15364579]
  The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.
  J Mol Biol 342, 1533-46
6.   Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB and Závodszky P (2003) [12538697]
  Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.
  J Immunol 170, 1374-82
7.   Varga L, Szilágyi K, Lőrincz Z, Berrens L, Thiel S, Závodszky P, Daha MR, Thielens NM, Arlaud GJ, Nagy K, Späth P and Füst G (2003) [12686499]
  Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement.
  Mol Immunol 39, 839-46
8.   Kardos J, Gál P, Szilágyi L, Thielens NM, Szilágyi K, Lőrincz Z, Kulcsár P, Gráf L, Arlaud GJ and Závodszky P (2001) [11673533]
  The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r.
  J Immunol 167, 5202-8
9.   Lörincz Z, Gál P, Dobó J, Cseh S, Szilágyi K, Ambrus G and Závodszky P (2000) [10925288]
  The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex.
  J Immunol 165, 2048-51
10.   Dobó J, Gál P, Szilágyi K, Cseh S, Lörincz Z, Schumaker VN and Závodszky P (1999) [9916740]
  One active C1r subunit is sufficient for the activity of the complement C1 complex: stabilization of C1r in the zymogen form by point mutations.
  J Immunol 162, 1108-12
11.   Gál P, Sárvári M, Szilágyi K, Závodszky P and Schumaker VN (1989) [2557186]
  Expression of hemolytically active human complement component C1r proenzyme in insect cells using a baculovirus vector.
  notSet 6, 433-41