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Beata Vertessy

Dictionary
Publications
Publications

Articles

1.   Nagy GN, Marton L, Krámos B, Oláh J, Révész A, Vékey K, Delsuc F, Hunyadi-Gulyás E, Medzihradszky KF, Lavigne M, Vial H, Cerdan R and Vértessy BG (2013) [23578277]
  Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.
  FEBS J notSet,
2.   Butykai A, Orbán A, Kocsis V, Szaller D, Bordács S, Tátrai-Szekeres E, Kiss LF, Bóta A, Vértessy BG, Zelles T and Kézsmárki I (2013) [23478535]
  Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.
  Sci Rep-uk 3, 1431
3.   Horváti K, Bacsa B, Szabó N, Dávid S, Mező G, Grolmusz V, Vértessy BG, Hudecz F and Bősze S (2012) [22515329]
  Enhanced Cellular Uptake of a New, in Silico Identified Antitubercular Candidate by Peptide Conjugation.
  Bioconjugate Chem 23, 900-7
4.   Horváth A, Békési A, Muha V, Erdélyi M and Vértessy BG (2012) [23238493]
  Expanding the DNA alphabet in the fruit fly: Uracil enrichment in genomic DNA.
  Fly 7,
5.   Magazu S, Migliardo F, Gonzalez MA, Mondelli C, Parker SF and Vertessy BG (2012) [-100052455]
  Molecular Mechanisms of Survival Strategies in Extreme Conditions.
  Life 2, 364-76
6.   Poppe L, Paizs C, Kovács K, Irimie FD and Vértessy B (2012) [21956553]
  Preparation of unnatural amino acids with ammonia-lyases and 2,3-aminomutases.
  Methods Mol Biol 794, 3-19
7.   Pecsi I, Hirmondo R, Brown AC, Lopata A, Parish T, Vertessy BG and Tóth J (2012) [22655049]
  The dUTPase Enzyme Is Essential in Mycobacterium smegmatis.
  PLoS ONE 7, e37461
8.   Muha V, Horváth A, Békési A, Pukáncsik M, Hodoscsek B, Merényi G, Róna G, Batki J, Kiss I, Jankovics F, Vilmos P, Erdélyi M and Vértessy BG (2012) [22685418]
  Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement.
  PLoS Genet 8, e1002738
9.   Bekesi A, Pukancsik M, Haasz P, Felfoldi L, Leveles I, Muha V, Hunyadi-Gulyas E, Erdei A, Medzihradszky KF and Vertessy BG (2011) [21134127]
  Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding.
  FEBS J 278, 295-315
10.   Bozóky Z, Róna G, Klement E, Medzihradszky KF, Merényi G, Vértessy BG and Friedrich P (2011) [21625588]
  Calpain-Catalyzed Proteolysis of Human dUTPase Specifically Removes the Nuclear Localization Signal Peptide.
  PLoS ONE 6, e19546
11.   Merényi G, Kovári J, Tóth J, Takács E, Zagyva I, Erdei A and Vértessy BG (2011) [21780905]
  Cellular Response to Efficient dUTPase RNAi Silencing in Stable HeLa Cell Lines Perturbs Expression Levels of Genes Involved in Thymidylate Metabolism.
  Nucleos Nucleot Nucl 30, 369-90
12.   Leveles I, Róna G, Zagyva I, Bendes A, Harmat V and Vértessy BG (2011) [22102244]
  Crystallization and preliminary crystallographic analysis of dUTPase from the ϕ11 helper phage of Staphylococcus aureus.
  Acta Crystallogr F 67, 1411-3
13.   Scheich C, Szabadka Z, Vértessy B, Pütter V, Grolmusz V and Schade M (2011) [22164290]
  Discovery of novel MDR-Mycobacterium tuberculosis inhibitor by new FRIGATE computational screen.
  PLoS ONE 6, e28428
14.   Vértessy BG and Orosz F (2011) [21053308]
  From fluctuation fit to conformational selection: evolution, rediscovery, and integration of a concept.
  Bioessays 33, 30-4
15.   Pécsi I, Szabó JE, Adams SD, Simon I, Sellers JR, Vértessy BG and Tóth J (2011) [21831832]
  Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination.
  P Natl Acad Sci Usa 108, 14437-14442
16.   Mészáros B, Tóth J, Vértessy BG, Dosztányi Z and Simon I (2011) [21814507]
  Proteins with Complex Architecture as Potential Targets for Drug Design: A Case Study of Mycobacterium tuberculosis.
  PLoS Comput Biol 7, e1002118
17.   Erdélyi P, Borsos E, Takács-Vellai K, Kovács T, Kovács AL, Sigmond T, Hargitai B, Pásztor L, Sengupta T, Dengg M, Pécsi I, Tóth J, Nilsen H, Vértessy BG and Vellai T (2011) [21502138]
  Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.
  J Cell Sci 124, 1510-8
18.   Horváth A and Vértessy BG (2010) [20864450]
  A one-step method for quantitative determination of uracil in DNA by real-time PCR.
  Nucleic Acids Res 38, e196
19.   Pecsi I, Leveles I, Harmat V, Vertessy BG and Toth J (2010) [20601405]
  Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase.
  Nucleic Acids Res 38, 7179-86
20.   Takács E, Nagy G, Leveles I, Harmat V, Lopata A, Tóth J and Vértessy BG (2010) [20493855]
  Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases.
  FEBS Lett 584, 3047-54
21.   Kovacs E, Tóth J, Vértessy BG and Liliom K (2010) [19910470]
  Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling.
  J Biol Chem 285, 1799-808
22.   Merényi G, Kónya E and Vértessy BG (2010) [20412059]
  Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals.
  FEBS J 277, 2142-56
23.   Pukáncsik M, Békési A, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kosinski J, Bujnicki JM, Alfonso C, Rivas G and Vértessy BG (2010) [20121948]
  Physiological truncation and domain organization of a novel uracil-DNA-degrading factor.
  FEBS J 277, 1245-59
24.   Kovacs E, Harmat V, Tóth J, Vértessy BG, Módos K, Kardos J and Liliom K (2010) [20522785]
  Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions.
  FASEB J 24, 3829-39
25.   Varga B, Migliardo F, Takacs E, Vertessy B, Magazù S and Telling MT (2010) [19795216]
  Study of solvent-protein coupling effects by neutron scattering.
  J Biol Phys 36, 207-20
26.   Spadiut O, Leitner C, Salaheddin C, Varga B, Vertessy BG, Tan TC, Divne C and Haltrich D (2009) [19143837]
  Improving thermostability and catalytic activity of pyranose 2-oxidase from Trametes multicolor by rational and semi-rational design.
  FEBS J 276, 776-92
27.   Vértessy BG and Tóth J (2009) [18837522]
  Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases.
  Accounts Chem Res 42, 97-106
28.   Takács E, Barabás O, Petoukhov MV, Svergun DI and Vértessy BG (2009) [19302784]
  Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers.
  FEBS Lett 583, 865-71
29.   Muha V, Zagyva I, Venkei Z, Szabad J and Vértessy BG (2009) [19232319]
  Nuclear localization signal-dependent and -independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage.
  Biochem Bioph Res Co 381, 271-5
30.   Varga B, Barabás O, Takács E, Nagy N, Nagy P and Vértessy BG (2008) [18519027]
  Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor.
  Biochem Bioph Res Co 373, 8-13
31.   Hill K, Pénzes CB, Vértessy BG, Szabadka Z, Grolmusz V and Kiss É (2008) [-100022486]
  Amphiphilic Nature of New Antitubercular Drug Candidates and Their Interaction with Lipid Monolayer.
  Prog Coll Pol Sci 135, 87-92
32.   Varga B, Migliardo F, Takács E, Vértessy BG and Magazu S (2008) [-100017974]
  Experimental study on dUTPase-inhibitor candidate and dUTPase/disaccharide mixtures by PCS and ENS
  J Mol Struct 886, 128-135
33.   Kovári J, Barabás O, Varga B, Békési A, Tölgyesi F, Fidy J, Nagy J and Vértessy BG (2008) [17932923]
  Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
  Proteins 71, 308-19
34.   Varga B , Migliardo F , Takacs E , Vertessy B , Magazu S and Mondelli C (2008) [-100031082]
  Neutron scattering studies on dUTPase complex in the presence of bioprotectant systems
  Chem Phys 345, 250-258
35.   Békési A, Pukáncsik M, Muha V, Zagyva I, Leveles I, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Kele Z, Erdei A, Felföldi F, Kónya E and Vértessy BG (2007) [17306761]
  A novel fruitfly protein under developmental control degrades uracil-DNA.
  Biochem Bioph Res Co 355, 643-8
36.   Varga B, Barabás O, Kovári J, Tóth J, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Tölgyesi F, Fidy J and Vértessy BG (2007) [17880943]
  Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
  FEBS Lett 581, 4783-8
37.   Németh-Pongrácz V, Barabás O, Fuxreiter M, Simon I, Pichová I, Rumlová M, Zábranská H, Svergun D, Petoukhov M, Harmat V, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kónya E and Vértessy BG (2007) [17169987]
  Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins.
  Nucleic Acids Res 35, 495-505
38.   Tóth J, Varga B, Kovács M, Málnási-Csizmadia A and Vértessy BG (2007) [17848562]
  Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme.
  J Biol Chem 282, 33572-82
39.   Barabas O, Nemeth V and Vertessy BG (2006) [-100002900]
  Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus.
  Acta Crystallogr F 62, 399-401
40.   Németh-Pongrácz V, Snasel J, Rumlova M, Pichova I and Vértessy BG (2006) [17065090]
  Interacting partners of M-PMV nucleocapsid-dUTPase.
  Nucleos Nucleot Nucl 25, 1197-200
41.   Lari SU, Chen CY, Vertéssy BG, Morré J and Bennett SE (2006) [16908222]
  Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance.
  Dna Repair 5, 1407-20
42.   Barabas O, Nemeth-pongracz V, Magyar A, Hudecz F and Vertessy BG (2006) [-100015042]
  Role of the C-terminal conserved sequence motif in the function of dutpase from Mason-pfizer monkey retrovirus
  J Pept Sci 12, 206-
43.   Takács E, Grolmusz VK and Vértessy BG (2004) [15147867]
  A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases.
  FEBS Lett 566, 48-54
44.   Kovári J, Barabás O, Takács E, Békési A, Dubrovay Z, Pongrácz V, Zagyva I, Imre T, Szabó P and Vértessy BG (2004) [14724274]
  Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.
  J Biol Chem 279, 17932-44
45.   Békési A, Zagyva I, Hunyadi-Gulyás E, Pongrácz V, Kovári J, Nagy AO, Erdei A, Medzihradszky KF and Vértessy BG (2004) [14996835]
  Developmental regulation of dUTPase in Drosophila melanogaster.
  J Biol Chem 279, 22362-70
46.   Kovári J, Imre T, Szabó P and Vértessy BG (2004) [15571280]
  Mechanistic studies of dUTPases.
  Nucleos Nucleot Nucl 23, 1475-9
47.   Dubrovay Z, Gáspári Z, Hunyadi-Gulyás E, Medzihradszky KF, Perczel A and Vértessy BG (2004) [14724273]
  Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer.
  J Biol Chem 279, 17945-50
48.   Barabás O, Pongrácz V, Kovári J, Wilmanns M and Vértessy BG (2004) [15208312]
  Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase.
  J Biol Chem 279, 42907-15
49.   Mustafi D, Bekesi A, Vertessy BG and Makinen MW (2003) [12721364]
  Catalytic and structural role of the metal ion in dUTP pyrophosphatase.
  P Natl Acad Sci Usa 100, 5670-5
50.   Barabás O, Rumlová M, Erdei A, Pongrácz V, Pichová I and Vértessy BG (2003) [12869552]
  dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency.
  J Biol Chem 278, 38803-12
51.   Vertessy BG, Magazu S, Mangione A, Migliardo F and Brandt A (2003) [-100002796]
  Structure of Escherichia coli dUTPase in solution: A small angle neutron scattering study.
  Macromol Biosci 3, 477-481
52.   Brandt A, Magazu S, Mangione A, Migliardo F and Vertessy BG (2002) [-100002749]
  Characterization of conformational properties of protein/trehalose/water system by neutron scattering.
  Collect Czech Chem C 74, S457-S458
53.   Branca C, Magazu S, Maidsano G, Migliardo F, Migliardo P, Romeo G and Vertessy BG (2001) [-100002729]
  Conformational studies of poly(ethylene oxide) in crystalline, molten and solution phase.
  Mol Cryst Liq Cryst 372, 17-23
54.   Vertessy BG (2001) [-100002669]
  dUTPases.
  Curr Protein Pept Sc 2,
55.   Harmat V, Böcskei Z, Náray-Szabó G, Bata I, Csutor AS, Hermecz I, Arányi P, Szabó B, Liliom K, Vértessy BG and Ovádi J (2000) [10731425]
  A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies.
  J Mol Biol 297, 747-55
56.   Fiser A and Vértessy BG (2000) [11118321]
  Altered subunit communication in subfamilies of trimeric dUTPases.
  Biochem Bioph Res Co 279, 534-42
57.   Vértessy BG, Bánkfalvi D, Kovács J, Löw P, Lehotzky A and Ovádi J (1999) [9918855]
  Pyruvate kinase as a microtubule destabilizing factor in vitro.
  Biochem Bioph Res Co 254, 430-5
58.   Vertessy BG, Harmat V, Böcskei Z, Náray-Szabó G, Orosz F and Ovádi J (1998) [9799490]
  Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.
  Biochemistry-us 37, 15300-10
59.   Vertessy BG, Larsson G, Persson T, Bergman AC, Persson R and Nyman PO (1998) [9462846]
  The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase.
  FEBS Lett 421, 83-8
60.   Vértessy BG, Orosz F, Kovács J and Ovádi J (1997) [9325270]
  Alternative binding of two sequential glycolytic enzymes to microtubules. Molecular studies in the phosphofructokinase/aldolase/microtubule system.
  J Biol Chem 272, 25542-6
61.   Vértessy BG, Kovács J, Löw P, Lehotzky A, Molnár A, Orosz F and Ovádi J (1997) [9047303]
  Characterization of microtubule-phosphofructokinase complex: specific effects of MgATP and vinblastine.
  Biochemistry-us 36, 2051-62
62.   Vertessy BG, Böcskei Z, Harmath V, Náray-Szabó G and Ovádi J (1997) [9144798]
  Crystallization and preliminary diffraction analysis of Ca(2+)-calmodulin-drug and apocalmodulin-drug complexes.
  Proteins 28, 131-4
63.   Vertessy BG (1997) [9261872]
  Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme.
  Proteins 28, 568-79
64.   Orosz F, Kovács J, Löw P, Vértessy BG, Urbányi Z, Acs T, Keve T and Ovádi J (1997) [9222552]
  Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity.
  Brit J Pharmacol 121, 947-54
65.   Ovádi J , Vértessy B G , Kovács J , Orosz F , Liliom K and Wágner G (1997) [-100008651]
  Multiple Functions of Glycolytic Kinases and Microtubular Proteins
  Cell Biol Int 21, 915-916
66.   Orosz F, Vértessy BG, Salerno C, Crifo C, Capuozzo E and Ovádi J (1997) [9222553]
  The interaction of a new anti-tumour drug, KAR-2 with calmodulin.
  Brit J Pharmacol 121, 955-62
67.   Lehotzky A , Kovács J , Molnár A , Vértessy B G , Orosz F and Ovádi J (1996) [-100009895]
  Drug-resistant cross-bridges of microtubules by phosphofructokinase: a molecular model.
  Cell Biol Int 20, 237
68.   Vertessy BG (1996) [-100009871]
  Functional role of the C-terminal flexible arm of E-coli deoxyuridine triphosphatase
  Prog Biophys Mol Bio 65, PMI20-
69.   Vértessy B G , Kovács J and Ovádi J (1996) [-100000724]
  Interaction of brain and muscle phosphofructokinase with map-containing microtubules
  Cell Biol Int 20, 239
70.   Vértessy BG, Kovács J and Ovádi J (1996) [8635590]
  Specific characteristics of phosphofructokinase-microtubule interaction.
  FEBS Lett 379, 191-5
71.   Vertessy BG, Persson R, Rosengren AM, Zeppezauer M and Nyman PO (1996) [8604980]
  Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site.
  Biochem Bioph Res Co 219, 294-300
72.   Orosz F, Vértessy BG, Hollán S, Horányi M and Ovádi J (1996) [8944178]
  Triosephosphate isomerase deficiency: predictions and facts.
  J Theor Biol 182, 437-47
73.   Molnár A, Liliom K, Orosz F, Vértessy BG and Ovádi J (1995) [8566178]
  Anti-calmodulin potency of indol alkaloids in in vitro systems.
  Eur J Pharmacol 291, 73-82
74.   Vertessy BG, Zalud P, Nyman PO and Zeppezauer M (1994) [8142479]
  Identification of tyrosine as a functional residue in the active site of Escherichia coli dUTPase.
  Biochim Biophys Acta 1205, 146-50
75.   Vertessy BG and Zeppezauer M (1994) [7958294]
  Identification of tyrosine as an active site residue involved in the catalytic mechanism of Escherichia coli dUTPase.
  Biochem Soc T 22, 233S
76.   Vértessy BG and Vas M (1992) [1417758]
  Metabolite channeling versus free diffusion: reinterpretation of aldolase-catalysed inactivation of glyceraldehyde-3-phosphate dehydrogenase.
  Biochem J 286 (Pt 3), 977-9
77.   Vértessy BG, Orosz F and Ovádi J (1991) [2065091]
  Modulation of the interaction between aldolase and glycerol-phosphate dehydrogenase by fructose phosphates.
  Biochim Biophys Acta 1078, 236-42
78.   Vertessy BG and Steck TL (1989) [2713438]
  Elasticity of the human red cell membrane skeleton. Effects of temperature and denaturants.
  Biophys J 55, 255-62
79.   Ovádi J, Tompa P, Vértessy B, Orosz F, Keleti T and Welch GR (1989) [2920010]
  Transient-time analysis of substrate-channelling in interacting enzyme systems.
  Biochem J 257, 187-90
80.   Welch GR, Keleti T and Vértessy B (1988) [3184958]
  The control of cell metabolism for homogeneous vs. heterogeneous enzyme systems.
  J Theor Biol 130, 407-22
81.   Keleti T, Vértessy B and Welch GR (1988) [3256718]
  The perfection of substrate-channelling in interacting enzyme systems: energetics and evolution.
  J Theor Biol 135, 75-83
82.   Vértessy B and Ovádi J (1987) [3569280]
  A simple approach to detect active-site-directed enzyme-enzyme interactions. The aldolase/glycerol-phosphate-dehydrogenase enzyme system.
  Eur J Biochem 164, 655-9
83.   Vértessy B, Vas M and Keleti T (1986) [3789735]
  Microenvironment of the enzyme-bound NADH is different in lobster and pig muscle glyceraldehyde-3-phosphate dehydrogenase microcrystals.
  Arch Biochem Biophys 251, 299-305

Books or book chapters

1.   Ovadi J, Vertessy BG, Kovacs J, Wagner G, Liliom K and Orosz F (1999)
  Interrelationship of cytoarchitecture and glucose metabolism.
  From Symbiosis to Eukariotism-Endocytobiology; VII. , 517-532
2.   Keleti T and Vertessy BG (1986)
  Kinetic power and theory of control in Dynamics of Biochemical Systems
  Symp. Biol. Hung. 30, 3-10