Course on

”Computational approches to structural biology”

in Hungarian

 

1. Introduction. Problems in structural biology. Modell generation

2. Force fields. Optimization techniques

3. Molecular dynamics calculations and their application in structure determination methods

4. Monte Carlo calculations. Biased sampling.

5. Structure-prediction methods. Homology modelling.

6. Microscopic and macroscopic approaches in computing electrostatic properties. pKa calculations

7. Free energy techniques

8. Quantum chemical description of chemical reactions

9. Modelling reactions in solution

10. Computing activation free energies of enzymatic reactions

11. Understanding enzymatic catalysis

12. Rational drug design.