DNA Binding Protein prediction
This server predicts whether a protein is DNA-binding from its structure and/or sequence. The algorithm is described in the following paper:
Szilagyi A, Skolnick J:
Efficient prediction of nucleic acid binding function from low-resolution protein structures.
J Mol Biol. 2006 May 5;358(3):922-33. Epub 2006 Mar 10. PubMed
Important note: The method was essentially developed to predict DNA binding ability from the three-dimensional structure of a protein. Although it can predict DNA binding from the protein sequence alone, pure sequence-based prediction was only validated on a very small set of sequences (all of them belonging to structures in the Protein Data Bank). Therefore, the actual false positive and false negative rates of purely sequence-based predictions could be higher than the estimate indicated here. A three-dimensional structure should be used as input to the server whenever possible.