Display conformation:

ATP-Bound Conformation Nucleotide-free Conformation

Conservative sequences:

Walker A Walker B Q loop Signature Nucleotide Binding Domains Transmembrane Helixes ATP

Mutations:

S317R I319V L355R S359S T364R T364M N370D L381L R382W R391G K392N S398G S398R N411K N411N V415A V415V C440G R487Q A455P L463H N466Y H475L R487Q L495H N497K T500P K502M V514I R518Q E521D S535P F551S M562T F568S A594V R600C V614A T630T H632Q Q655R G663C P664S V665A G666W L673P L677P Q698P E699D R724K V725V L726P I742V M751K G755R R760W R760Q R765W R765Q A766D D777N A781V N793L G800G R807W R807Q V810M T811M A820P L826P A830A M848V T944I P945P P945P L946I A950T F952C L953H R964P L968L Q981H G992R L1025P G1042S S1049A D1056E L1063R R1064W R1114C R1114P R1114H S1121L S1121W M1127T M1127I T1130M G1133C G1133A R1138W R1138Q R1138P A1139T R1164Q G1203D R1221C R1221H L1226I E1234V R1235W D1238H Y1239H W1241C G1263R R1268Q R1273K A1291T E1293K V1298F G1299S T1301I G1302R A1303P S1307P G1311E R1314W R1314Q G1321S D1326D L1335P L1335Q R1339C R1339H R1339L I1342T P1346S Q1347H I1350L G1354R R1357W D1361N K1394N E1400K S1403R G1405S R1418Q R1418R I1424T G1435G G1481S P1483L G1501S

Download

ATP-Bond Conformation pdb file
Nucleotide-free Conformation pdb file

Reference

Fulop K, Symmons O, Zavodszky P and Varadi A (2009)
Clustering of disease-causing mutations on the domain-domain interfaces of ABCC6.
Biochem Biophys Res Commun 379, 706-9 The homology model of Human ABCC6 protein.